Jeffersonville, IN to Locke, IN is 252.6 miles and takes about 5h 7m via North Meridian Street and I-65/I-69, with a fuel budget near $39 and enough daylight to finish in a day. This trip stays within the Midwest region, traversing Indiana for its entirety. Expect a mix of highway cruising and surface street driving as you make your way north. With a recommended one-day drive, this route is a straightforward option for connecting these two Indiana locations.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
126.3 miles from Jeffersonville, IN
A natural place for your longest stop of the day
, about 2h 24m into the drive
.
Main Roads
Road
Distance
Duration
North Meridian Street
105 mi
2h 10m
I 65
101.9 mi
1h 50m
I 69
14 mi
16m
Grand Army of the Republic Highway
13.6 mi
18m
Keystone Parkway
5 mi
7m
I 465
2.9 mi
3m
South Emerson Avenue
2.5 mi
4m
County Road 3
1.5 mi
3m
Longest stretch:
North Meridian Street
— 105 mi, about 2h 10m
Traffic on I-65
Hour-of-day weekday pattern from 48 FHWA count stations on your route.
Peak
4 PM
~3,790 veh/hr typical
Quietest
1 AM
~398 veh/hr
Peak-to-quiet ratio
9.5×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 50 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Jeffersonville, IN and Locke, IN.
1
Start on Watt Street
257 ft·13 sec·Watt Street
2
Turn right onto East Court Avenue
0.4 mi·1 min·East Court Avenue
3
Turn slight right onto 6th Street
0.3 mi·45 sec·6th Street
4
Take the ramp
0.2 mi·28 sec
5
Merge onto I 65
102 mi·1 hr 50 min·I 65
6
Take the exit
0.4 mi·47 sec
Exit 103Toward Southport RoadUse the slight right lane.
7
Turn slight right
176 ft·4 sec
8
Turn straight onto East Southport Road
0.2 mi·26 sec·East Southport Road
9
Turn left onto South Emerson Avenue
2.5 mi·4 min·South Emerson Avenue
Use the left lane.
10
Take the ramp
0.5 mi·58 sec
11
Merge onto I 69; I 74; I 465
2.3 mi·2 min·I 69; I 74; I 465
12
Continue on I 69; I 465
12 mi·13 min·I 69; I 465
13
Keep slight left at fork onto I 465
0.3 mi·19 sec·I 465
14
Continue on I-465 WB
0.8 mi·56 sec·I-465 WB
15
Continue on I 465
2.6 mi·3 min·I 465
Use the straight lane.
16
Take the exit
0.4 mi·52 sec
Exit 33Toward Keystone AvenueUse the slight right lane.
17
Turn right
172 ft·6 sec
Toward North Keystone Parkway, West 96th Street, West 98th Street, East 96th StreetUse the slight right lane.
18
Merge onto North Keystone Avenue
0.3 mi·44 sec·North Keystone Avenue
Use the right lane.
19
Enter roundabout
113 ft·6 sec
Toward North Keystone Parkway, East 98th Street
20
Continue
0.2 mi·30 sec
Toward North Keystone Parkway, East 98th Street
21
Keep slight left at fork
436 ft·11 sec
Toward Keystone Parkway
22
Merge onto Keystone Parkway
5.0 mi·7 min·Keystone Parkway
23
Merge onto US 31
105 mi·2 hr 10 min·North Meridian Street
24
Take the exit
0.3 mi·37 sec
Toward US 6: Walkerton, Bremen
25
Turn right onto US 6
14 mi·18 min·Grand Army of the Republic Highway
26
Continue on US 6
1.0 mi·1 min·West Market Street
27
Turn left onto North Arnott Street
0.5 mi·1 min·North Arnott Street
28
Continue on CR 3
1.5 mi·3 min·County Road 3
29
Turn right onto CR 50
0.4 mi·1 min·County Road 50
30
Arrive at destination
CR 50
Trip Plan
To make the most of this 5-hour drive, consider departing in the morning to allow for flexibility. The route is manageable in a single day, so you can choose to stop whenever you need a break. Keep an eye on your fuel, especially when you're on the longer surface road stretches where gas stations might be less frequent. Given the 105-mile segment on North Meridian Street, planning a fuel stop before entering that section could be beneficial.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 126.3 miles from Jeffersonville, IN, or about 2h 24m into the drive.
The longest continuous stretch on this route runs about 105 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 56 miles or 1h 2m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 126.3 miles or 2h 24m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 5m
Traffic, exits, and arrival timing usually matter more near Locke, IN than in the middle of the route.
Before You Leave
+
Open the route before leaving Jeffersonville, IN so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Jeffersonville, IN
This is one driving day of about 252.6 miles and 5h 7m.
Your first comfortable stop window is around 56 miles from Jeffersonville, IN.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on North Meridian Street for about 105 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 18
5 decision points cluster between mile 102.8 and 124.9 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
7
102.8 mi into trip|~1h 52m in
Take the exit toward Southport Road
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight right lane.
Exit 103
Toward Southport Road
7
124.2 mi into trip|~2h 19m in
Take the exit toward Keystone Avenue
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight right lane.
Exit 33
Toward Keystone Avenue
7
124.6 mi into trip|~2h 20m in
Turn right toward North Keystone Parkway, West 96th Street, West 98th Street, East 96th Street
Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Toward North Keystone Parkway, West 96th Street...
7
124.6 mi into trip|~2h 20m in|North Keystone Avenue
Merge onto North Keystone Avenue
Merge point - match speed before joining. Lane positioning matters here
Use the right lane.
7
124.9 mi into trip|~2h 21m in
Enter roundabout toward North Keystone Parkway, East 98th Street
Roundabout - know your exit number before entering. Multiple destination signs - pick the right one
Toward North Keystone Parkway, East 98th Street
Fuel & Cost
Regular Gas
$42.00 one way
$83.99 round trip
$4.22/gal25.4 MPG avg88 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.60
$45.75
$91.49
premium
$5.18
$51.54
$103.09
diesel
$5.35
$53.21
$106.41
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$42
Meals
$25–$50
Total
$67–$92
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 88.4 kg one way.
Prices: EIA weekly data, 2026-06-01.
Driving Electric?
About $27 in charging
· 0 stops
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
75.8
0
$26.52
$12.12
Efficient EV
63.2
0
$22.10
$10.10
EV Truck/SUV
101
1
$35.36
$16.17
Gas CO2
88 kg
EV CO2
30 kg (66% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Jun 1, 2026
Origin
Jeffersonville, IN
Afternoon
in Jeffersonville on Wednesday
Local time
3:06 PM
EDT
Current temp
60°F
Partly Cloudy
NE 1 mph3% chanceLive forecast
Flood Warning
Flood Warning issued May 31 at 9:10PM EDT until June 2 at 6:00AM EDT by NWS Indianapolis IN
Flood Warning
Flood Warning issued May 31 at 9:10PM EDT until June 3 at 12:48PM EDT by NWS Indianapolis IN
Destination
Locke, IN
Afternoon
in Locke on Wednesday
Local time
3:06 PM
EDT
Current temp
54°F
Mostly Cloudy
NE 5 mph7% chanceLive forecast
Flood Warning
Flood Warning issued May 31 at 9:10PM EDT until June 2 at 6:00AM EDT by NWS Indianapolis IN
Flood Warning
Flood Warning issued May 31 at 9:10PM EDT until June 3 at 12:48PM EDT by NWS Indianapolis IN
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
6 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 7m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
This route features 49% highway driving, with the longest continuous stretch on surface roads being 105 miles on North Meridian Street. You'll experience a transition from highway speeds on I-65 and I-69 to navigating through towns and local traffic as you move onto surface streets. Be prepared for merging and exiting on the interstate sections before encountering more varied driving conditions.
49% highway, the rest on surface roads — varied driving throughout.
30 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 105 mi on North Meridian Street.
How Hard Is This Drive?
9/10
This route mixes highway mileage with some local-road sections near the start or finish. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 102.8 miles in.
Driving Effort9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 18 significant decision points across 252.6 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 102.8 miles: Exit ramp - move to the correct lane early. Lane positioning matters here; at 124.2 miles: Exit ramp - move to the correct lane early. Lane positioning matters here; at 124.6 miles: Lane positioning matters here. Multiple destination signs - pick the right one.
Elevation Profile
Mostly flat terrain
908 ft444 ft
Total Climb
656 ft
Total Descent
225 ft
Highest Point
908 ft
~144.3 mi in
Elevation Range
463 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from Jeffersonville, IN to Locke, IN, road signs begin pointing toward Bremen along the way.
Jeffersonville, often called "Jeff" by locals, is the county seat of Clark County in Southern Indiana, on the opposite side of the Ohio River from Louisville, Kentucky and connected to Louisville by the Kennedy, Lincoln, and Lewis and Clark Bridges. It has a population of 48,000 (2019).
Top landmarks
•George Rogers Clark Memorial Bridge — crossing of the Ohio River between Louisville, Kentucky, and Jeffersonville, Ind...
•Spring Street Freight House — constructed in 1925
Doable as a same-day drive at 5h 7m. Total distance: 252.6 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 7m drive, comfortable solo distance.
Frequently Asked Questions
The longest stretch is about 105 miles on North Meridian Street. The full list of main roads is in the Roads section above.
Yes — we found about 13 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Locke, IN before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. There are 13 rest areas along the route for bathroom stops.
The main spots that need attention: at 102.8 miles: Exit ramp - move to the correct lane early. Lane positioning matters here; at 124.2 miles: Exit ramp - move to the correct lane early. Lane positioning matters here; at 124.6 miles: Lane positioning matters here. Multiple destination signs - pick the right one.
Not recommended in a single day. At 5.1 hours each way, a round trip means 10.3 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Locke, IN before the return drive.
