Origin
Jefferson, NC
Late night in Jefferson on Sunday
Local time
3:29 AM
EDT
Current temp
45°F
Unavailable
Live forecast
Trip from Jefferson, NC to Durham, NC
Compiled and reviewed by the US Trip Planner planning team at COD Solutions Oy · Last reviewed Apr 19, 2026 · Editorial standards
Drive Time
3h 27m
Distance
165.6 mi
267 km
Drive Score
8/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$26
one way
EV Charging
Unknown
Best Time to Leave
4 AM
3h 15m
★
6 AM
3h 27m
8 AM
3h 51m
10 AM
3h 36m
12 PM
3h 33m
3 PM
3h 37m
5 PM
3h 50m
8 PM
3h 20m
Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.
Jefferson, NC
Wikimedia Commons
Trip Overview
This 165.6-mile drive from Jefferson, NC to Durham, NC is easily manageable as a single-day trip, taking approximately 3 hours and 27 minutes. The route is primarily highway, making it a straightforward journey with a predicted fuel cost of around $26. You'll be spending almost all your time on major roads, with only a small portion on local highways. Given its efficient travel time and the fact that both the origin and destination are within the Southeast region and the state of North Carolina, this trip is ideal for a quick getaway or an easy transfer between locations without the need for an overnight stop.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Break Rhythm
1 planned break
A short stop every 2 to 3 hours is enough for this drive.
Midpoint
82.8 miles from Jefferson, NC
A natural place for your longest stop of the day , about 1h 48m into the drive .
Main Roads
| Road | Distance | Duration |
|---|---|---|
| I 40 | 69.4 mi | 1h 21m |
| Watson Brame Expressway | 52.3 mi | 1h 2m |
| NC 16 | 25.8 mi | 37m |
| I 85 | 9.4 mi | 10m |
| Durham Freeway | 5.2 mi | 6m |
| East Main Street | 1.7 mi | 3m |
| South Roxboro Street | 0.4 mi | <1m |
| J W Luke Road | 0.2 mi | <1m |
Longest stretch:
I 40
— 69.4 mi, about 1h 21m
Turn-by-Turn Driving Directions
Step-by-step road directions between Jefferson, NC and Durham, NC.
1
Start on US 221 Business; NC 88
0.8 mi
·
1 min
·
East Main Street
2
Turn left onto US 221; NC 88
0.9 mi
·
2 min
·
East Main Street
3
Continue on NC 16; NC 88
3.1 mi
·
4 min
·
NC 16; NC 88
4
Turn right onto NC 16
3.8 mi
·
5 min
·
NC 16
5
Turn right onto J W Luke Road
0.2 mi
·
15 sec
·
J W Luke Road
6
Turn slight left onto Trading Post Road
217 ft
·
3 sec
·
Trading Post Road
7
Turn right onto NC 16
19 mi
·
27 min
·
NC 16
8
Turn left onto US 421
52 mi
·
1 hr 2 min
·
Watson Brame Expressway
Use the straight / right lanes.
9
Take the exit
1.0 mi
·
2 min
Exit 238
Toward I 40 East: Greensboro
Use the straight / slight right lanes.
10
Merge onto I 40
23 mi
·
26 min
·
I 40
Use the straight / slight right lanes.
11
Keep slight right at fork onto I 40
7.8 mi
·
9 min
·
I 40
Toward I 40 East: Greensboro, Martinsville
Use the straight / slight right lanes.
12
Merge onto I 40; US 29; US 220
1.8 mi
·
2 min
·
I 40; US 29; US 220
Use the straight / slight right lanes.
13
Keep slight left at fork onto I 40
37 mi
·
42 min
·
I 40
Use the straight / slight right lanes.
14
Keep slight left at fork onto I 85; NC 86 Truck
9.4 mi
·
10 min
·
I 85; NC 86 Truck
Toward I 85 North: Durham
Use the straight / slight right lanes.
15
Keep slight right at fork onto NC 147
5.2 mi
·
6 min
·
Durham Freeway
Toward NC 147 South: Downtown Durham, Duke University, North Carolina Central University, Research Triangle Park
Use the straight / slight right lanes.
16
Take the exit
512 ft
·
12 sec
Toward Mangum Street, Roxboro Street
Use the slight right lane.
17
Continue on Morehead Avenue
0.2 mi
·
29 sec
·
Morehead Avenue
Use the straight lane.
18
Turn left onto US 15 Business; US 501 Business
0.4 mi
·
58 sec
·
South Roxboro Street
Use the left lane.
19
Turn left onto East Main Street
100 ft
·
2 sec
·
East Main Street
Use the straight / left lanes.
20
Arrive at destination
East Main Street
Trip Plan
With a total travel time of just over 3.5 hours, this route offers plenty of flexibility for when you depart. Leaving Jefferson, NC in the morning allows you to arrive in Durham, NC by midday, leaving your afternoon open. The longest stretch without a significant change in road type is 69.4 miles on I-40, so plan your first fuel or rest stop before or shortly after this segment if needed. At only 165.6 miles, you can easily complete this trip on a single tank of gas, but it's always wise to check your gauge, especially when covering the 69.4-mile stretch on I-40. Consider a brief stop around the halfway point to stretch your legs and stay refreshed.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 82.8 miles from Jefferson, NC, or about 1h 48m into the drive.
The longest continuous stretch on this route runs about 69.4 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 36 miles or 51m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 82.8 miles or 1h 48m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 2h 50m
Traffic, exits, and arrival timing usually matter more near Durham, NC than in the middle of the route.
Before You Leave
+
Open the route before leaving Jefferson, NC so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Jefferson, NC
This is one driving day of about 165.6 miles and 3h 27m.
Your first comfortable stop window is around 36 miles from Jefferson, NC.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 40 for about 69.4 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Mid-route town
Meal stop
83 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
Pacing Suggestions
Fuel and coffee
A short stop after about 36 miles helps settle the day before fatigue starts building.
Meal break
The midpoint is around 82.8 miles from Jefferson, NC, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel checkTop up before I 40 if your tank is already low. That segment runs about 69.4 miles.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Heads-up: tricky spots
5 of 155 decision points cluster between mile 80 and 165 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
7
80 mi into trip
|
~1h 43m in
Take the exit toward I 40 East: Greensboro
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the straight / slight right lanes.
Exit 238
Toward I 40 East: Greensboro
8
104.1 mi into trip
|
~2h 12m in
|
I 40
Keep slight right at fork onto I 40 toward I 40 East: Greensboro, Martinsville
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward I 40 East: Greensboro, Martinsville
7
150.4 mi into trip
|
~3h 7m in
|
I 85; NC 86 Truck
Keep slight left at fork onto I 85; NC 86 Truck toward I 85 North: Durham
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight / slight right lanes.
Toward I 85 North: Durham
8
159.8 mi into trip
|
~3h 18m in
|
NC 147 / Durham Freeway
Keep slight right at fork onto NC 147 / Durham Freeway toward NC 147 South: Downtown Durham, Duke University, North Carolina Central University, Research Triangle Park
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward NC 147 South: Downtown Durham, Duke Univ...
7
165 mi into trip
|
~3h 25m in
Take the exit toward Mangum Street, Roxboro Street
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Toward Mangum Street, Roxboro Street
Fuel & Cost
Regular Gas
$25.90 one way
$51.79 round trip
$3.97/gal
25.4 MPG avg
58 kg CO2
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.34 | $28.31 | $56.63 |
| premium | $4.70 | $30.65 | $61.30 |
| diesel | $5.61 | $36.56 | $73.12 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$26
Meals
$25–$50
Total
$51–$76
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 57.9 kg one way. Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $17 in charging · 0 stops · 67% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 49.7 | 0 | $17.39 | $7.95 |
| Efficient EV | 41.4 | 0 | $14.49 | $6.62 |
| EV Truck/SUV | 66.2 | 0 | $23.18 | $10.60 |
Gas CO2
58 kg
EV CO2
19 kg (67% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Destination
Durham, NC
Late night in Durham on Sunday
Local time
3:29 AM
EDT
Current temp
50°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
5 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
3h 27m on the road
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
What kind of drive is this?
Expect a highway-focused experience for 98% of this 165.6-mile route. You'll be covering significant ground on I-40, which forms the longest uninterrupted stretch of 69.4 miles. The journey will largely feel like a continuous flow on well-maintained interstates and expressways, including Watson Brame Expressway and NC 16. This profile suggests a drive that prioritizes speed and directness over winding scenic byways, allowing you to cover distance efficiently. The road character remains consistent for the majority of the trip, offering a predictable driving environment.
98% highway — fuel and pacing are the main things to plan.
20 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 69.4 mi on I 40.
How Hard Is This Drive?
8/10
This is a straightforward highway drive that stays mostly on I 40 and Watson Brame Expressway. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 80 miles in.
Driving Effort
8/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 15 significant decision points across 165.6 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 80 miles: Exit ramp - move to the correct lane early. Lane positioning matters here; at 104.1 miles (I 40): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 150.4 miles (I 85; NC 86 Truck): Highway fork - watch signs carefully. Lane positioning matters here.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from Jefferson, NC to Durham, NC, road signs begin pointing toward Martinsville along the way.
Martinsville
104.1 mi in
|
~2h 12m
|
via I 40
About the Cities
Arriving in Durham, NC
Full guide →Of the three cities that make up North Carolina's Research Triangle, Durham has traditionally been the one with the grittier, more working-class image. A city of just over 300,000 residents in 2026, Durham has moved beyond a "tobacco town" with a prestigious university at its center to become a regionally and nationally recognized symbol of urban renewal, gentrification, technology and diversity. Durham's vibrant African-American community was historically pioneering in United States Black culture, from the arts to finance. These days, the tobacco warehouses and textile mills have been converted to other uses, as Durham has taken on a much more high-profile (and expensive) identity. Thanks to local anchor Duke University, a thriving, research-driven medical and tech industry has taken root.
City content from Wikivoyage (CC BY-SA 4.0) and Wikidata (CC0).
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 3h 27m. Total distance: 165.6 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
3h 27m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (98%). Some complex stretches to watch for.
Frequently Asked Questions
The longest stretch is about 69.4 miles on I 40. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Durham, NC before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 80 miles: Exit ramp - move to the correct lane early. Lane positioning matters here; at 104.1 miles (I 40): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 150.4 miles (I 85; NC 86 Truck): Highway fork - watch signs carefully. Lane positioning matters here.
Possible but tiring. At 3.5 hours each way, an in-and-out day trip would put you behind the wheel for 6.9 hours — manageable with a long break at Durham, NC, but most travelers stay overnight.
How this page is built
Compiled by the US Trip Planner planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, and EIA for fuel prices. See our methodology for refresh cadence and limitations.
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