This 58.4-mile drive from Indiana, IA, to Ankeny, IA, is a straightforward journey perfect for a single-day trip, taking approximately 1 hour and 14 minutes. Primarily following State Highway 5, also known as the Military Order of the Purple Heart Highway, about 70% of this route is on highways, offering a smooth and efficient passage through the Midwest. With an estimated fuel cost of $9, this is an economical option for those looking to travel between these two Iowa locations. You'll find this drive to be a practical and uncomplicated way to get where you're going, with no overnight stays required.