Holtsville to Amherst is 424.8 miles and takes about 8h 55m via New York State Thruway, with a fuel budget near $69 and enough daylight to finish in a day. This drive stays within New York, taking you across the state. With a recommended two days for this trip, you'll have plenty of time to break up the driving and enjoy the scenery. The route primarily uses major highways, making it a straightforward option for getting from Long Island to Western New York.
Trip Pace
Best split across 2 days
Treat the return leg as its own travel day rather than an afterthought.
Break Rhythm
2 planned breaks
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
212.4 miles from Holtsville, NY
A natural place for your longest stop of the day
, about 4h 26m into the drive
.
Main Roads
Road
Distance
Duration
New York State Thruway
99.6 mi
1h 55m
I 81
97.3 mi
1h 55m
Christopher Columbus Highway
68.2 mi
1h 20m
Long Island Expressway
37.2 mi
49m
I 380
27.7 mi
30m
Keystone Shortway
17.3 mi
24m
Clinton Street
10.5 mi
15m
East Lake Road
9.9 mi
14m
Longest stretch:
New York State Thruway
— 99.6 mi, about 1h 55m
Traffic on I-80
Hour-of-day weekday pattern from 168 FHWA count stations on your route.
Peak
3 PM
~4,210 veh/hr typical
· worst 4,900
Quietest
1 AM
~430 veh/hr
Peak-to-quiet ratio
9.8×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 52 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Holtsville, NY and Amherst, NY.
1
Start on Union Avenue
76 ft·8 sec·Union Avenue
2
Turn left onto Waverly Avenue
0.5 mi·1 min·Waverly Avenue
3
Turn left onto Express Drive North
0.8 mi·1 min·Express Drive North
4
Take the ramp
0.2 mi·21 sec
Toward I-495 west: New York
5
Merge onto I 495
37 mi·49 min·Long Island Expressway
Use the straight / slight right lanes.
6
Take the exit
0.2 mi·27 sec
Exit 31N-SToward Cross Island Parkway, Whitestone Bridge, Kennedy AirportUse the straight / slight right lanes.
7
Keep slight right at fork
0.3 mi·38 sec
Exit 31NToward Cross Island Parkway North, Whitestone BridgeUse the slight left / slight right lanes.
8
Merge onto CI
3.1 mi·4 min·Cross Island Parkway
Use the straight / slight right lanes.
9
Take the exit
0.6 mi·1 min
Exit 33Toward I 295 North: Throgs Neck Bridge, Bronx, New EnglandUse the straight / slight right lanes.
10
Merge onto I 295
1.8 mi·3 min·Throgs Neck Bridge
11
Continue on I 295
0.7 mi·1 min·Throgs Neck Expressway
Use the straight / slight right lanes.
12
Keep slight left at fork onto I 295
6.6 mi·8 min·Cross Bronx Expressway
Use the straight / slight right lanes.
13
Keep slight left at fork onto I 95; US 1
0.7 mi·1 min·Trans-Manhattan Expressway
Toward Upper Level
14
Continue on I 95; US 1
0.6 mi·59 sec·George Washington Bridge (upper level)
15
Continue on I 95 EXPR; US 1 EXPR; US 9 EXPR
0.5 mi·48 sec·I 95 EXPR; US 1 EXPR; US 9 EXPR
16
Keep slight left at fork onto I 95 EXPR; US 1 EXPR; US 9 EXPR
0.6 mi·39 sec·I 95 EXPR; US 1 EXPR; US 9 EXPR
Use the straight / slight right lanes.
17
Keep slight left at fork onto I 95 EXPR; NJTP
0.1 mi·8 sec·I 95 EXPR; NJTP
18
Take the exit
0.2 mi·22 sec
Toward I 95 South, NJTP South: HackensackUse the straight / slight right lanes.
19
Keep slight left at fork
0.4 mi·29 sec
Toward I 95 South, NJTP South: HackensackUse the slight left / slight right lanes.
20
Merge onto I 95; NJTP
2.0 mi·2 min·New Jersey Turnpike
Use the straight / slight right lanes.
21
Take the exit
0.8 mi·1 min
Exit 69Toward I 80 West: Paterson, HackensackUse the straight / slight right lanes.
22
Continue on I 80
68 mi·1 hr 20 min·Christopher Columbus Highway
Use the straight / slight right lanes.
23
Keep slight left at fork onto I 80
5.5 mi·8 min·Keystone Shortway
Use the straight / slight right lanes.
24
Keep slight left at fork onto I 80
12 mi·15 min·Keystone Shortway
25
Take the exit
0.7 mi·46 sec
Exit 293Toward I 380 North: Scranton
26
Continue on I 380
28 mi·30 min·I 380
Use the straight lane.
27
Merge onto I 81
58 mi·1 hr 9 min·I 81
Use the straight lane.
28
Keep slight right at fork onto I 81
1.8 mi·2 min·I 81
Toward I 81 North: Syracuse, Albany
29
Keep slight left at fork onto I 81
37 mi·43 min·I 81
Toward I 81 North: Syracuse
30
Take the exit
0.1 mi·21 sec
Exit 52Toward NY 13: Cortland
31
Turn right onto NY 13
39 ft·5 sec·Clinton Avenue
32
Turn left onto Locust Avenue
1.2 mi·2 min·Locust Avenue
33
Continue on Albany Street
0.6 mi·1 min·Albany Street
34
At end of road, turn right onto US 11; NY 41
0.4 mi·1 min·South Main Street
35
Turn left onto NY 41
10 mi·15 min·Clinton Street
36
Continue on NY 41
0.5 mi·49 sec·East Lake Road
37
Continue on NY 41
4.8 mi·7 min·State Route 41
38
Continue on NY 41
9.4 mi·13 min·East Lake Road
39
Continue on NY 41
0.5 mi·48 sec·East Lake Street
40
Turn left onto US 20
7.3 mi·13 min·East Genesee Street
41
Turn right onto US 20
0.2 mi·12 sec·North Fulton Street
42
Turn left onto US 20; NY 5
0.4 mi·1 min·Arterial West
43
Continue on US 20; NY 5; NY 38
9.8 mi·11 min·Chase Street
Use the left lane.
44
Continue on US 20; NY 5
1.9 mi·2 min·Auburn Road
45
Turn right onto NY 318
4.1 mi·7 min·NY 318
46
Continue on NY 318
319 ft·10 sec·NY 318
Use the right lane.
47
Turn right onto NY 414
0.3 mi·28 sec·State Route 414
Use the right lane.
48
Continue on NY 414
217 ft·11 sec·Ridge Road
Use the left lane.
49
Take the ramp
0.2 mi·23 sec
Use the left lane.
50
Keep slight left at fork
0.6 mi·1 min
Toward I 90 West: BuffaloUse the straight / right lanes.
51
Merge onto I 90
100 mi·1 hr 55 min·New York State Thruway
52
Take the exit
0.4 mi·36 sec
Exit 50Toward I 290: Niagara FallsUse the straight / slight right lanes.
53
Continue on I 290
1.8 mi·2 min·Youngmann Expressway
54
Take the exit
0.2 mi·29 sec
Exit 6Toward NY 324, NY 240: Sheridan Drive, Harlem RoadUse the straight / slight right lanes.
55
Turn left onto NY 324
0.9 mi·1 min·Sheridan Drive
Use the left / right lanes.
56
Turn left onto NY 263
469 ft·13 sec·Millersport Highway
Use the left lane.
57
Arrive at destination
NY 263
Trip Plan
Given the 8h 55m estimated drive time, splitting this into two days is a smart move, especially with two recommended stops. Aim to depart early in the morning to maximize your daylight hours, whether you're pushing through or taking your time. The longest stretch without a major highway change is nearly 100 miles, so plan your fuel and rest breaks accordingly. Keep an eye on your fuel gauge as you move from the more developed eastern part of the state toward the western regions, where services might be spaced further apart.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
This drive is better paced as a 2-day trip.
Plan roughly 2 meaningful breaks for fuel, food, and rest.
The halfway point lands around 212.4 miles from Holtsville, NY, or about 4h 26m into the drive.
The longest continuous stretch on this route runs about 99.6 miles.
Consider an overnight stop or starting very early.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 93 miles or 2h 3m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 212.4 miles or 4h 26m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Overnight split
Day 1 wrap after about 212.4 miles or 4h 26m
Stop before fatigue turns the last few hours into a grind. You want day two to start fresh, not just resumed.
Final approach
Final hour starts around 7h 44m
Traffic, exits, and arrival timing usually matter more near Amherst, NY than in the middle of the route.
Before You Leave
+
Open the route before leaving Holtsville, NY so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
+
Pick one backup stop option before the midpoint in case traffic changes your pacing.
+
Treat this as a 2-day road trip and book the overnight stop before the busiest arrival window.
Day 1
Settle into the route from Holtsville, NY
Aim for roughly 212 miles and 4.5 hours of wheel time on this day.
Day 2
Finish the approach into Amherst, NY
Aim for roughly 212 miles and 4.5 hours of wheel time on this day.
Your first comfortable stop window is around 93 miles from Holtsville, NY.
This route usually feels better as a 2-day drive than as one long push.
Plan about 2 real breaks rather than only quick fuel stops.
The longest stretch is on New York State Thruway for about 99.6 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 40
5 decision points cluster between mile 38.6 and 54.7 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
8
38.6 mi into trip|~52m in
Take the exit toward Cross Island Parkway, Whitestone Bridge, Kennedy Airport
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Exit 31N-S
Toward Cross Island Parkway, Whitestone Bridge,...
10
38.9 mi into trip|~53m in
Keep slight right at fork toward Cross Island Parkway North, Whitestone Bridge
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Exit 31N
Toward Cross Island Parkway North, Whitestone B...
8
42.2 mi into trip|~58m in
Take the exit toward I 295 North: Throgs Neck Bridge, Bronx, New England
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Exit 33
Toward I 295 North: Throgs Neck Bridge, Bronx,...
8
54.4 mi into trip|~1h 16m in
Take the exit toward I 95 South, NJTP South: Hackensack
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward I 95 South, NJTP South: Hackensack
8
54.7 mi into trip|~1h 16m in
Keep slight left at fork toward I 95 South, NJTP South: Hackensack
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward I 95 South, NJTP South: Hackensack
Fuel & Cost
Regular Gas
$68.72 one way
$137.44 round trip
$4.11/gal25.4 MPG avg149 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.46
$74.57
$149.15
premium
$4.85
$81.08
$162.16
diesel
$4.80
$80.21
$160.42
Estimated Tolls: $27.81
George Washington Bridge
$16.00
Throgs Neck Bridge
$6.55
New York State Thruway
(99.6 mi)$4.98
New Jersey Turnpike
(2 mi)$0.28
Toll estimates based on average 2024-2025 rates. EZ-Pass/SunPass discounts may lower the actual cost.
Estimated Trip Cost (one way, 1 person)
Fuel
$69
Tolls
$28
Hotel (1n)
$80–$140
Meals
$50–$100
Total
$227–$337
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 148.6 kg one way.
Prices: EIA weekly data, 2026-07-13.
Driving Electric?
About $45 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
127.4
1
$44.60
$20.39
Efficient EV
106.2
1
$37.17
$16.99
EV Truck/SUV
169.9
2
$59.47
$27.19
Gas CO2
149 kg
EV CO2
50 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Jul 17, 2026
Origin
Holtsville, NY
Late night
in Holtsville on Sunday
Local time
4:58 AM
EDT
Current temp
70°F
Smoke
NW 7 mph6% chanceLive forecast
Destination
Amherst, NY
Late night
in Amherst on Sunday
Local time
4:58 AM
EDT
Current temp
63°F
Smoke
N 5 mph0% chanceLive forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
For long drives, weather on day two can matter just as much as conditions at departure, so check the whole travel window rather than only the first day.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
7 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
8h 55m on the road
This is long enough that the arrival forecast matters almost as much as departure conditions. Recheck both ends before you roll.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Harriet Tubman National Historical Park
National Historical Park
Harriet Tubman was guided by a deep faith and devotion to family, freedom, and community. After emancipating herself and members of her family, she moved them from Ontario, Canada to Fleming and Aubur...
3 mi from route
~7 min detour
Free
near mile 307.6
The final resting place of President Ulysses S. Grant and his wife, Julia, is the largest mausoleum in North America. It testifies to a people’s gratitude for the man who ended the bloodiest conflict...
5 mi from route
~13 min detour
Free
near mile 58.6
Women’s Rights National Historical Park tells the story of the first Women’s Rights Convention, held in Seneca Falls, New York on July 19-20, 1848. It is a story of struggles for civil rights, human r...
5 mi from route
~11 min detour
Free
near mile 322.3
Merchant’s clerk, Revolutionary War soldier, first Secretary Treasury of the United States: Alexander Hamilton’s life is memorialized at The Grange, the home he built on a country estate in uptown Man...
6 mi from route
~14 min detour
Free
near mile 58.6
Immerse yourself in an enchanting collage of coastal life and history. Rhythmic waves, high dunes, ancient maritime forests, historic landmarks and glimpses of wildlife, Fire Island has been a special...
Before the 1960s, almost everything about living authentically as a lesbian, a bisexual person or a gay man was illegal. The Stonewall Uprising on June 28, 1969 is a milestone in the quest for civil r...
9 mi from route
~23 min detour
Free
near mile 58.6
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
About 44% of this trip is on highways, with the longest continuous highway stretch being 99.6 miles on the New York State Thruway. After the highway sections, you'll transition to mostly surface roads for the remainder of the 424.8 miles. Expect a mix of highway cruising and navigating through more developed areas with frequent exits as you approach your destination.
Only 44% highway — the rest is turn-by-turn surface driving.
57 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 99.6 mi on New York State Thruway.
How Hard Is This Drive?
10/10
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 38.6 miles in.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 40 significant decision points across 424.8 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 38.6 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 38.9 miles: Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 42.2 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Elevation Profile
Hilly terrain with moderate elevation changes
1,951 ft48 ft
Total Climb
3,017 ft
Total Descent
2,526 ft
Highest Point
1,951 ft
~151.7 mi in
Elevation Range
1,903 ft
Notable High Points
1,951 ft at ~151.7 miles+550 ft prominence
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Holtsville, NY and Amherst, NY, road signs point toward Kennedy Airport, Cross Island Parkway North, Bronx, New England, Upper Level and Njtp South: Hackensack - among others.
Mostly surface roads route profile with national parks nearby.
Frequently Asked Questions
The longest stretch is about 99.6 miles on New York State Thruway. The full list of main roads is in the Roads section above.
Yes — a 2-day pace is more comfortable than one long haul. A sensible stopping point is after roughly 212 miles on day one.
Expect about $27.81 in tolls one way, starting with George Washington Bridge. Most Northeast and Midwest toll agencies accept E-ZPass; in the West and Texas, transponders like TxTag or FasTrak apply. If you do not have a transponder, cashless tolling plates will mail a bill to the vehicle's registered address — usually with a surcharge, so a rental-car toll pass is often cheaper than paying by mail.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Amherst, NY before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 2 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 38.6 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 38.9 miles: Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 42.2 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Yes — Harriet Tubman National Historical Park, General Grant National Memorial and Women's Rights National Historical Park (6 total within detour distance). See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 8.9 hours each way, a round trip means 17.9 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Amherst, NY before the return drive.
