If you are planning a trip from Henderson to Greenville, you can expect a straightforward journey covering 93 miles. Driving time typically clocks in at about 2 hours and 3 minutes, making this an easy candidate for a single-day excursion. You will primarily rely on US 64 Bypass, US 13, and Andrews Avenue to navigate between these two Southeast North Carolina cities. With a fuel budget of approximately $15, the trip is quite economical for a solo driver or a small group. Since the entire drive takes place within the same region, you won't experience drastic shifts in landscape, allowing for a consistent travel pace. It is a highly practical route that works perfectly if you want to get from point A to point B without the need for an overnight stay.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Midpoint
46.5 miles from Henderson, NC
A natural place for your longest stop of the day
, about 1h 8m into the drive
.
Main Roads
Road
Distance
Duration
US 64 Bypass
26.5 mi
29m
US 13
13.2 mi
16m
Andrews Avenue
11.7 mi
18m
US 64
10.6 mi
11m
NC 58
10.5 mi
15m
NC 56 Highway East
5.4 mi
9m
Firetower Road
4.8 mi
6m
Duke Valentine Wynne Road
3.1 mi
4m
Longest stretch:
US 64 Bypass
— 26.5 mi, about 29m
Turn-by-Turn Driving Directions
Step-by-step road directions between Henderson, NC and Greenville, NC.
1
Start on US 1 BUS; US 158 BUS
19 ft·9 sec·North Garnett Street
2
Turn left onto NC 39
12 mi·18 min·Andrews Avenue
3
Turn left onto Wilson-Fuller Road
0.9 mi·1 min·Wilson-Fuller Road
4
At end of road, turn right onto US 401
0.5 mi·50 sec·US 401
5
Turn left onto Trinity Church Road
2.1 mi·2 min·Trinity Church Road
6
Turn right onto Duke Valentine Wynne Road
3.1 mi·4 min·Duke Valentine Wynne Road
7
At end of road, turn left onto NC 561
0.1 mi·13 sec·NC 561
8
Turn right onto Firetower Road
4.8 mi·6 min·Firetower Road
9
Turn left onto NC 56
5.4 mi·9 min·NC 56 Highway East
10
At end of road, turn right onto NC 58
11 mi·15 min·NC 58
11
Take the ramp
0.2 mi·26 sec
Toward NC 58: Nashville, Castalia
12
Merge onto US 64 Bypass
27 mi·29 min·US 64 Bypass
13
Continue on US 64; US 258; NC 111; NC 122
11 mi·11 min·US 64; US 258; NC 111; NC 122
14
Take the exit
0.3 mi·43 sec
Toward US 13 South, NC 11: Bethel, Greenville
15
Turn right onto US 13; NC 11
13 mi·16 min·US 13; NC 11
16
Turn left onto NC 33
1.9 mi·3 min·North Greene Street
Use the straight / left lanes.
17
Continue on South Pitt Street
0.4 mi·46 sec·South Pitt Street
18
Turn left onto West 1st Street
0.5 mi·1 min·West 1st Street
19
Turn right onto South Summit Street
448 ft·19 sec·South Summit Street
20
Arrive at destination
South Summit Street
Trip Plan
Because this is a relatively short trip, you have plenty of flexibility regarding your departure time. You can comfortably complete the drive in one go without needing to plan for formal stops, as the 2-hour duration is manageable for most drivers. Keep an eye on your fuel gauge before heading out, though with a $15 cost, it is easy to budget for a full tank before you leave Henderson. Since there are zero required stops built into the itinerary, you have the freedom to pull over whenever you feel like stretching your legs. My top tip for this specific drive is to stay alert when transitioning off the US 64 Bypass onto the local segments, as the shift in speed limits and road character requires your full attention.
Morning Departure
Leave by 9 AM and you'll arrive before lunch.
Evening Departure
Even a 4 PM departure gets you there before dark in summer.
You can normally do this drive in one day.
You may only need one short stretch break if traffic stays light.
The halfway point lands around 46.5 miles from Henderson, NC, or about 1h 8m into the drive.
The longest continuous stretch on this route runs about 26.5 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 20 miles or 30m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 46.5 miles or 1h 8m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 1h 40m
Traffic, exits, and arrival timing usually matter more near Greenville, NC than in the middle of the route.
Before You Leave
+
Open the route before leaving Henderson, NC so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Henderson, NC
This is one driving day of about 93 miles and 2h 3m.
Your first comfortable stop window is around 20 miles from Henderson, NC.
This route can stay practical as a one-day drive if traffic stays reasonable.
The longest stretch is on US 64 Bypass for about 26.5 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 15
5 decision points cluster between mile 0 and 90.1 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
4
0 mi into trip|~0m in|NC 39 / Andrews Avenue
Turn left onto NC 39 / Andrews Avenue
Navigation decision point
5
18.4 mi into trip|~27m in|NC 561
At end of road, turn left onto NC 561
Navigation decision point
5
39.2 mi into trip|~59m in
Take the ramp toward NC 58: Nashville, Castalia
Multiple destination signs - pick the right one
Toward NC 58: Nashville, Castalia
5
76.5 mi into trip|~1h 40m in
Take the exit toward US 13 South, NC 11: Bethel, Greenville
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward US 13 South, NC 11: Bethel, Greenville
6
90.1 mi into trip|~1h 58m in|NC 33 / North Greene Street
Turn left onto NC 33 / North Greene Street
Lane positioning matters here
Use the straight / left lanes.
Fuel & Cost
Regular Gas
$14.54 one way
$29.09 round trip
$3.97/gal25.4 MPG avg33 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.34
$15.90
$31.80
premium
$4.70
$17.21
$34.42
diesel
$5.61
$20.53
$41.07
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$15
Meals
$25–$50
Total
$40–$65
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 32.5 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $10 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
27.9
0
$9.76
$4.46
Efficient EV
23.3
0
$8.14
$3.72
EV Truck/SUV
37.2
0
$13.02
$5.95
Gas CO2
33 kg
EV CO2
11 kg (67% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 17, 2026
Origin
Henderson, NC
Morning
in Henderson on Sunday
Local time
6:01 AM
EDT
Current temp
56°F
Unavailable
Live forecast
Destination
Greenville, NC
Morning
in Greenville on Sunday
Local time
6:01 AM
EDT
Current temp
57°F
Unavailable
Live forecast
72°F
Nashville, NC
47 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
1 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
2h 3m on the road
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
Expect a highway-focused experience, as roughly 72% of this trip is spent on major thoroughfares. You will find a steady rhythm behind the wheel, especially during the longest uninterrupted stretch of 26.5 miles on the US 64 Bypass. While the route is designed for efficiency, the transition between high-speed highway sections and the local segments along Andrews Avenue keeps the driving experience varied. The roads are built for consistent movement, so you should encounter few interruptions throughout the 93-mile trek. Overall, the drive feels utilitarian and direct, favoring speed and reliability over winding, technical turns.
72% highway — fuel and pacing are the main things to plan.
20 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 26.5 mi on US 64 Bypass.
How Hard Is This Drive?
3/10
This is a straightforward highway drive that stays mostly on US 64 Bypass and US 13. There are only a few real navigation decisions along the way. The trickiest moment comes early in the drive near NC 39 / Andrews Avenue.
Driving Effort3/10
Easy - simple navigation with a manageable amount of wheel time
Balances navigation complexity with total wheel time.
This is a straightforward 2h 3m drive. You will face about 15 decision points, but nothing that requires special attention if you follow navigation.
Where does it get tricky?
The main spots that need attention: near the start (NC 39 / Andrews Avenue): Navigation decision point; at 18.4 miles (NC 561): Navigation decision point; at 39.2 miles: Multiple destination signs - pick the right one.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from Henderson, NC to Greenville, NC, road signs begin pointing toward Castalia along the way.
Greenville, one of the fastest growing cities in North Carolina, is the county seat of Pitt County, and is
the principal city of the Greenville, North Carolina metropolitan area. Greenville is known as the cultural, economical, and educational hub of North Carolina's Inner Banks, the geographical area east of Raleigh and west of the North Carolina coast.
The longest stretch is about 26.5 miles on US 64 Bypass. The full list of main roads is in the Roads section above.
Yes, with realistic expectations. Build in a stop roughly every 2 hours, have snacks and activities ready, and check the Nearby Places tabs for kid-friendly stops along the way.
The main spots that need attention: near the start (NC 39 / Andrews Avenue): Navigation decision point; at 18.4 miles (NC 561): Navigation decision point; at 39.2 miles: Multiple destination signs - pick the right one.
Yes. A round trip is manageable in a single day if you plan a break at Greenville, NC before heading back.
