This 272.2-mile drive from Hempstead, NY to Manlius, NY will take approximately 5 hours and 40 minutes. It's a manageable one-day trip, so you can leave in the morning and arrive by late afternoon. The estimated fuel cost is around $45, which is quite reasonable for a trip of this length. You'll primarily travel on I-81, Christopher Columbus Highway, and I-380. This route stays within the Northeast region, offering a straightforward journey across New York.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
136.1 miles from Hempstead, NY
A natural place for your longest stop of the day
, about 2h 52m into the drive
.
Main Roads
Road
Distance
Duration
I 81
111.5 mi
2h 11m
Christopher Columbus Highway
68.2 mi
1h 20m
I 380
27.7 mi
30m
Keystone Shortway
17.3 mi
24m
Cross Bronx Expressway
6.6 mi
8m
Henneberry Road
6.5 mi
9m
Clearview Expressway
5 mi
5m
State Route 80
2.8 mi
4m
Longest stretch:
I 81
— 111.5 mi, about 2h 11m
Turn-by-Turn Driving Directions
Step-by-step road directions between Hempstead, NY and Manlius, NY.
1
Start on Peninsula Boulevard
77 ft·1 sec·Peninsula Boulevard
2
Turn left onto Clinton Street
359 ft·17 sec·Clinton Street
Use the left lane.
3
Turn left onto NY 102
1.1 mi·1 min·Front Street
4
Turn slight left onto NY 24
2.0 mi·3 min·Hempstead Turnpike
5
Turn right onto New Hyde Park Road
0.4 mi·53 sec·New Hyde Park Road
6
Turn left onto Tulip Avenue
2.0 mi·3 min·Tulip Avenue
Use the left lane.
7
Turn left onto NY 25
0.7 mi·1 min·Jamaica Avenue
8
Turn slight right onto NY 25
1.2 mi·2 min·Braddock Avenue
9
Turn left onto NY 25
0.7 mi·1 min·Hillside Avenue
10
Turn right onto I 295
5.0 mi·5 min·Clearview Expressway
Toward I 295 North: Clearview Expressway, Through Neck BridgeUse the straight / right lanes.
11
Continue on I 295
2.0 mi·3 min·Throgs Neck Bridge
12
Continue on I 295
0.7 mi·1 min·Throgs Neck Expressway
Use the straight / slight right lanes.
13
Keep slight left at fork onto I 295
6.6 mi·8 min·Cross Bronx Expressway
Use the straight / slight right lanes.
14
Keep slight left at fork onto I 95; US 1
0.7 mi·1 min·Trans-Manhattan Expressway
Toward Upper Level
15
Continue on I 95; US 1
0.6 mi·59 sec·George Washington Bridge (upper level)
16
Continue on I 95 EXPR; US 1 EXPR; US 9 EXPR
0.5 mi·48 sec·I 95 EXPR; US 1 EXPR; US 9 EXPR
17
Keep slight left at fork onto I 95 EXPR; US 1 EXPR; US 9 EXPR
0.6 mi·39 sec·I 95 EXPR; US 1 EXPR; US 9 EXPR
Use the straight / slight right lanes.
18
Keep slight left at fork onto I 95 EXPR; NJTP
0.1 mi·8 sec·I 95 EXPR; NJTP
19
Take the exit
0.2 mi·22 sec
Toward I 95 South, NJTP South: HackensackUse the straight / slight right lanes.
20
Keep slight left at fork
0.4 mi·29 sec
Toward I 95 South, NJTP South: HackensackUse the slight left / slight right lanes.
21
Merge onto I 95; NJTP
2.0 mi·2 min·New Jersey Turnpike
Use the straight / slight right lanes.
22
Take the exit
0.8 mi·1 min
Exit 69Toward I 80 West: Paterson, HackensackUse the straight / slight right lanes.
23
Continue on I 80
68 mi·1 hr 20 min·Christopher Columbus Highway
Use the straight / slight right lanes.
24
Keep slight left at fork onto I 80
5.5 mi·8 min·Keystone Shortway
Use the straight / slight right lanes.
25
Keep slight left at fork onto I 80
12 mi·15 min·Keystone Shortway
26
Take the exit
0.7 mi·46 sec
Exit 293Toward I 380 North: Scranton
27
Continue on I 380
28 mi·30 min·I 380
Use the straight lane.
28
Merge onto I 81
58 mi·1 hr 9 min·I 81
Use the straight lane.
29
Keep slight right at fork onto I 81
1.8 mi·2 min·I 81
Toward I 81 North: Syracuse, Albany
30
Keep slight left at fork onto I 81
52 mi·1 hr·I 81
Toward I 81 North: Syracuse
31
Take the exit
0.1 mi·24 sec
Exit 66Toward NY 80: TullyUse the straight / slight right lanes.
32
Turn left onto NY 281
453 ft·14 sec·State Route 281
33
Turn right onto US 11; NY 80
0.7 mi·1 min·Elm Street
34
Continue on NY 80
0.4 mi·1 min·Clinton Street
35
Continue on NY 80
2.8 mi·4 min·State Route 80
36
Turn left onto Berry Road
2.6 mi·3 min·Berry Road
37
Continue on Collins Road
1.2 mi·1 min·Collins Road
38
Turn straight onto Berwyn Road
2.1 mi·2 min·Berwyn Road
39
Turn slight right onto US 20
0.4 mi·44 sec·Route 20
40
Turn left onto Henneberry Road
6.5 mi·9 min·Henneberry Road
41
At end of road, turn right onto NY 173
0.7 mi·1 min·East Seneca Turnpike
42
Continue on NY 173
1.0 mi·2 min·West Seneca Street
43
Arrive at destination
NY 92; NY 173
Trip Plan
For this 5-hour, 40-minute drive, consider an early morning departure from Hempstead to maximize your daylight hours and avoid potential traffic. With only one recommended stop, you have flexibility in pacing. Keep an eye on your fuel levels, especially before embarking on the longest 111.5-mile stretch on I-81, as services can be more spread out on interstates. This trip is well-suited for a single day, but if you prefer a more relaxed pace, an overnight stop could be easily incorporated.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 136.1 miles from Hempstead, NY, or about 2h 52m into the drive.
The longest continuous stretch on this route runs about 111.5 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 60 miles or 1h 20m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 136.1 miles or 2h 52m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 35m
Traffic, exits, and arrival timing usually matter more near Manlius, NY than in the middle of the route.
Before You Leave
+
Open the route before leaving Hempstead, NY so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Hempstead, NY
This is one driving day of about 272.2 miles and 5h 40m.
Your first comfortable stop window is around 60 miles from Hempstead, NY.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 81 for about 111.5 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 26
5 decision points cluster between mile 8.1 and 253.8 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
7
8.1 mi into trip|~15m in|I 295 / Clearview Expressway
Turn right onto I 295 / Clearview Expressway toward I 295 North: Clearview Expressway, Through Neck Bridge
Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / right lanes.
Toward I 295 North: Clearview Expressway, Throu...
8
24.9 mi into trip|~37m in
Take the exit toward I 95 South, NJTP South: Hackensack
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward I 95 South, NJTP South: Hackensack
8
25.2 mi into trip|~38m in
Keep slight left at fork toward I 95 South, NJTP South: Hackensack
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward I 95 South, NJTP South: Hackensack
8
27.5 mi into trip|~41m in
Take the exit toward I 80 West: Paterson, Hackensack
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Exit 69
Toward I 80 West: Paterson, Hackensack
7
253.8 mi into trip|~5h 10m in
Take the exit toward NY 80: Tully
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the straight / slight right lanes.
Exit 66
Toward NY 80: Tully
Fuel & Cost
Regular Gas
$44.81 one way
$89.61 round trip
$4.18/gal25.4 MPG avg95 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.52
$48.45
$96.90
premium
$4.92
$52.76
$105.52
diesel
$5.61
$60.10
$120.20
Estimated Tolls: $23.02
George Washington Bridge
$16.00
Throgs Neck Bridge
$6.55
New Jersey Turnpike
(2 mi)$0.28
Hempstead Turnpike
(2 mi)$0.14
East Seneca Turnpike
(0.7 mi)$0.05
Toll estimates based on average 2024-2025 rates. EZ-Pass/SunPass discounts may lower the actual cost.
Estimated Trip Cost (one way, 1 person)
Fuel
$45
Tolls
$23
Meals
$25–$50
Total
$93–$118
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 95.2 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $29 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
81.7
1
$28.58
$13.07
Efficient EV
68.1
0
$23.82
$10.89
EV Truck/SUV
108.9
1
$38.11
$17.42
Gas CO2
95 kg
EV CO2
32 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 16, 2026
Origin
Hempstead, NY
Late night
in Hempstead on Sunday
Local time
3:45 AM
EDT
Current temp
59°F
Mostly Cloudy then Slight Chance Rain Showers
W 6 to 12 mph18% chanceLive forecast
Severe Thunderstorm Warning
Severe Thunderstorm Warning issued April 16 at 6:57PM EDT until April 16 at 8:00PM EDT by NWS Albany NY
Severe Thunderstorm Warning
Severe Thunderstorm Warning issued April 16 at 6:56PM EDT until April 16 at 7:30PM EDT by NWS Burlington VT
Destination
Manlius, NY
Late night
in Manlius on Sunday
Local time
3:45 AM
EDT
Current temp
42°F
Unavailable
Live forecast
49°F
Ramapo, NY
136 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
17 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 40m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
General Grant National Memorial
National Memorial
The final resting place of President Ulysses S. Grant and his wife, Julia, is the largest mausoleum in North America. It testifies to a people’s gratitude for the man who ended the bloodiest conflict...
4 mi from route
~11 min detour
Free
near mile 28.2
Caution: Lower Crypt Access Subject to Safe Conditions
Merchant’s clerk, Revolutionary War soldier, first Secretary Treasury of the United States: Alexander Hamilton’s life is memorialized at The Grange, the home he built on a country estate in uptown Man...
5 mi from route
~12 min detour
Free
near mile 18.8
Before the 1960s, almost everything about living authentically as a lesbian, a bisexual person or a gay man was illegal. The Stonewall Uprising on June 28, 1969 is a milestone in the quest for civil r...
9 mi from route
~23 min detour
Free
near mile 28.2
The African Burial Ground stands as the oldest and largest known excavated burial site in North America for both free and enslaved Africans. It offers a profound testament to the enduring legacy of Af...
10 mi from route
~26 min detour
Free
near mile 28.2
Located at the southern tip of Manhattan, Castle Clinton marks the place where New York City began and reflects the growth of both the city and the nation. Built to defend the harbor during the War of...
11 mi from route
~28 min detour
Free
near mile 28.2
Here at Federal Hall, George Washington took the oath of office as the first President of the United States, marking the beginning of the American constitutional republic. This historic site served as...
11 mi from route
~27 min detour
Free
near mile 28.2
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This route offers a mixed driving experience, with 59% of it being on highways. You'll encounter a substantial stretch of 111.5 miles on I-81, which is the longest uninterrupted segment. Expect a blend of faster highway driving and potentially some more varied road conditions as you navigate between the main thoroughfares. The overall profile suggests a drive that balances efficiency with moments of changing scenery and road type.
59% highway, the rest on surface roads — varied driving throughout.
43 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 111.5 mi on I 81.
How Hard Is This Drive?
10/10
This route mixes highway mileage with some local-road sections near the start or finish. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 8.1 miles in near I 295 / Clearview Expressway.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 26 significant decision points across 272.2 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 8.1 miles (I 295 / Clearview Expressway): Lane positioning matters here. Multiple destination signs - pick the right one; at 24.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 25.2 miles: Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Hempstead, NY and Manlius, NY, road signs point toward Upper Level, Njtp South: Hackensack, Hackensack and Albany.
Hempstead is the most populous town in America, with a whopping 700,000 residents, located on the South Shore of Nassau County, New York. The town is highly urbanized and fragmented, containing 22 semi-autonomous villages within its boundaries, and forty other neighborhoods.
Garden City, encompassing the "Nassau Hub" region, has its own article. The other prominent communities in Hempstead include Floral Park, Hempstead Village, Valley Stream, Rockville Centre, Freeport, Merrick, and the Five Towns area.
Top landmarks
•Mitchel Air Force Base — US Air Force base in Long Island, New York
Doable as a same-day drive at 5h 40m. Total distance: 272.2 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 40m drive, comfortable solo distance.
Scenic Drive
Mixed highway & surface route profile with national parks nearby.
Frequently Asked Questions
The longest stretch is about 111.5 miles on I 81. The full list of main roads is in the Roads section above.
Expect about $23.02 in tolls one way, starting with George Washington Bridge. Most Northeast and Midwest toll agencies accept E-ZPass; in the West and Texas, transponders like TxTag or FasTrak apply. If you do not have a transponder, cashless tolling plates will mail a bill to the vehicle's registered address — usually with a surcharge, so a rental-car toll pass is often cheaper than paying by mail.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Manlius, NY before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 8.1 miles (I 295 / Clearview Expressway): Lane positioning matters here. Multiple destination signs - pick the right one; at 24.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 25.2 miles: Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Yes — General Grant National Memorial, Hamilton Grange National Memorial and Stonewall National Monument (6 total within detour distance). See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 5.7 hours each way, a round trip means 11.3 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Manlius, NY before the return drive.
