This 25.7-mile drive from Frankfort Square to Cicero, Illinois, will take approximately 43 minutes, making it a perfect day trip. You'll navigate local roads, primarily using Harlem Avenue and South Cicero Avenue, with a brief stint on Southwest Highway. With a modest estimated fuel cost of $4, this journey through the Midwest region is straightforward and doesn't require an overnight stay. There are no designated stops on this route, but its short duration allows for plenty of flexibility. Consider this a convenient local transit rather than an epic adventure.