Connecting Dubuque to Des Moines, this 188.9-mile journey across Iowa is a straightforward trek that fits perfectly into a single day of travel. You can expect to spend about 3 hours and 46 minutes behind the wheel, making it an efficient way to cross the state. With a fuel budget of approximately $29, this trip is quite economical for solo drivers or families alike. Because the route stays entirely within the Midwest, you will experience consistent regional landscapes throughout your drive. Whether you are heading to the capital for business or a change of scenery, this one-day itinerary offers a practical transition between these two distinct Iowa hubs.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Break Rhythm
1 planned break
A short stop every 2 to 3 hours is enough for this drive.
Midpoint
94.4 miles from Dubuque, IA
A natural place for your longest stop of the day
, about 1h 53m into the drive
.
Main Roads
Road
Distance
Duration
US 151
58.1 mi
1h 7m
Lincoln Highway
37.3 mi
43m
Marshalltown Boulevard
33.7 mi
39m
73rd Street
24.4 mi
28m
IA 100
15.2 mi
18m
US 61
5.6 mi
7m
US 65
4.5 mi
5m
John MacVicar Freeway
4 mi
5m
Longest stretch:
US 151
— 58.1 mi, about 1h 7m
Turn-by-Turn Driving Directions
Step-by-step road directions between Dubuque, IA and Des Moines, IA.
1
Start on Central Avenue
0.2 mi·33 sec·Central Avenue
2
Take the ramp
0.2 mi·28 sec
Exit 189AToward US 61 South, US 151 South
3
Continue on US 61; US 151
5.6 mi·7 min·US 61; US 151
4
Take the exit onto US 151
57 mi·1 hr 6 min·US 151
5
Turn left onto US 151; IA 13
1.1 mi·1 min·US 151; IA 13
6
Turn right onto IA 100
15 mi·18 min·IA 100
7
Take the exit
0.7 mi·1 min
Toward US 30 West, US 218 North: Tama, Marshalltown
8
Merge onto US 30; US 218
2.4 mi·2 min·16th Avenue Southwest
9
Continue on US 30; US 218
24 mi·28 min·73rd Street
10
Continue on US 30
37 mi·43 min·Lincoln Highway
11
Take the exit
0.3 mi·46 sec
Toward IA 330: Melbourne, Des Moines
12
Turn left onto IA 330
34 mi·39 min·Marshalltown Boulevard
13
Continue on US 65; IA 330
0.7 mi·58 sec·Northeast Hubbell Avenue
14
Take the exit onto US 65
4.5 mi·5 min·US 65
Toward I 80 west, US 65 south: Des MoinesUse the straight / slight right lanes.
15
Take the exit
0.6 mi·1 min
Exit 137AToward I 235 West: Des MoinesUse the slight left lane.
16
Continue on John MacVicar Freeway
4.0 mi·5 min·John MacVicar Freeway
Toward I 235 West: Des MoinesUse the straight / slight right lanes.
17
Take the exit
0.3 mi·38 sec
Exit 8BToward East 6th Street, Pennsylvania Avenue, East VillageUse the slight right lane.
18
Keep slight right at fork
0.3 mi·44 sec
Toward East Village, East 6th Street, Penn AvenueUse the slight right lane.
19
Turn right onto Pennsylvania Avenue
0.3 mi·34 sec·Pennsylvania Avenue
20
Turn left onto East University Avenue
100 ft·8 sec·East University Avenue
21
Arrive at destination
East University Avenue
Trip Plan
To keep your 3-hour and 46-minute drive comfortable, plan for at least one scheduled stop to break up the journey. Leaving in the morning is your best bet to avoid potential congestion, especially when transitioning onto the busier segments of Marshalltown Boulevard. Since the total fuel cost is estimated at $29, you can easily manage your budget by topping off your tank before you leave Dubuque. Because this is a relatively short trip, you have the flexibility to adjust your pace based on traffic conditions or your own energy levels. Keep a close watch on your odometer during that initial 58.1-mile stretch on US 151 to gauge your progress effectively before hitting the mid-route transition.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 94.4 miles from Dubuque, IA, or about 1h 53m into the drive.
The longest continuous stretch on this route runs about 58.1 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 42 miles or 50m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 94.4 miles or 1h 53m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 3m
Traffic, exits, and arrival timing usually matter more near Des Moines, IA than in the middle of the route.
Before You Leave
+
Open the route before leaving Dubuque, IA so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Dubuque, IA
This is one driving day of about 188.9 miles and 3h 46m.
Your first comfortable stop window is around 42 miles from Dubuque, IA.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 151 for about 58.1 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 13
5 decision points cluster between mile 0.2 and 188.2 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
0.2 mi into trip|~0m in
Take the ramp toward US 61 South, US 151 South
Multiple destination signs - pick the right one
Exit 189A
Toward US 61 South, US 151 South
7
178.8 mi into trip|~3h 31m in|US 65
Take the exit onto US 65 toward I 80 west, US 65 south: Des Moines
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward I 80 west, US 65 south: Des Moines
7
183.3 mi into trip|~3h 37m in
Take the exit toward I 235 West: Des Moines
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight left lane.
Exit 137A
Toward I 235 West: Des Moines
8
187.9 mi into trip|~3h 43m in
Take the exit toward East 6th Street, Pennsylvania Avenue, East Village
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 8B
Toward East 6th Street, Pennsylvania Avenue, Ea...
8
188.2 mi into trip|~3h 44m in
Keep slight right at fork toward East Village, East 6th Street, Penn Avenue
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Toward East Village, East 6th Street, Penn Aven...
Fuel & Cost
Regular Gas
$29.53 one way
$59.06 round trip
$3.97/gal25.4 MPG avg66 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$32.43
$64.85
premium
$4.89
$36.35
$72.70
diesel
$5.61
$41.71
$83.41
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$30
Meals
$25–$50
Total
$55–$80
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 66.1 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $20 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
56.7
0
$19.83
$9.07
Efficient EV
47.2
0
$16.53
$7.56
EV Truck/SUV
75.6
0
$26.45
$12.09
Gas CO2
66 kg
EV CO2
22 kg (67% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 16, 2026
Origin
Dubuque, IA
Night
in Dubuque on Saturday
Local time
9:47 PM
CDT
Current temp
47°F
Unavailable
Live forecast
Destination
Des Moines, IA
Night
in Des Moines on Saturday
Local time
9:47 PM
CDT
Current temp
52°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
5 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
3h 46m on the road
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
This mixed-drive route balances fast-paced highway segments with more moderate travel, keeping the experience varied for the driver. With 46% of the trip spent on highways, you will encounter a blend of traffic patterns as you navigate US 151, the Lincoln Highway, and Marshalltown Boulevard. You will face your longest uninterrupted stretch early on, covering 58.1 miles on US 151 before the road character shifts. The transition from the corridors of eastern Iowa toward the central part of the state provides a steady rhythm without becoming overly monotonous. Expect a functional drive that requires your focus as you move between these primary thoroughfares.
46% highway, the rest on surface roads — varied driving throughout.
21 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 58.1 mi on US 151.
How Hard Is This Drive?
6/10
This route mixes highway mileage with some local-road sections near the start or finish. You will hit about 13 points where you need to pay attention to lane position or signs. The trickiest moment comes around 0.2 miles in.
Driving Effort6/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 188.9 miles you will encounter 13 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: at 0.2 miles: Multiple destination signs - pick the right one; at 178.8 miles (US 65): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 183.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from Dubuque, IA to Des Moines, IA, road signs begin pointing toward Marshalltown along the way.
Des Moines, capital of Iowa, is in the western region of the American Midwest. Des Moines is the largest city in Iowa and the annual site of the Iowa State Fair and numerous cultural festivals during warm weather months. History enthusiasts will find 110 historic sites in and around the city as part of the Silos and Smokestacks National Heritage Area. The city appeals to travelers with an interest in the arts who marvel at the architecture of the State Capitol with its five domes, including the large main dome with its gleaming 23-karat gold surface. The city has a good art museum, a symphony that performs in the downtown Civic Center (along with opera, ballet, and other performing arts), and a big annual arts festival that draws visitors from across Iowa and beyond.
Doable as a same-day drive at 3h 46m. Total distance: 188.9 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
3h 46m drive, comfortable solo distance.
Frequently Asked Questions
The longest stretch is about 58.1 miles on US 151. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Des Moines, IA before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 0.2 miles: Multiple destination signs - pick the right one; at 178.8 miles (US 65): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 183.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here.
Possible but tiring. At 3.8 hours each way, an in-and-out day trip would put you behind the wheel for 7.5 hours — manageable with a long break at Des Moines, IA, but most travelers stay overnight.
