Clinton, MS to Itawamba County, MS is 223.9 miles and takes about 4h 35m via MS Hwy 25 and US Hwy 45 Alternate, with a fuel budget near $33 and enough daylight to finish in a day. This trip stays within Mississippi, moving from the Southeast region to the Southeast region. Expect a mostly highway profile for the majority of the drive. It's a manageable distance for a single day, making it a straightforward option if you're looking to cover ground without an overnight commitment.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
111.9 miles from Clinton, MS
A natural place for your longest stop of the day
, about 2h 17m into the drive
.
Main Roads
Road
Distance
Duration
MS Hwy 25
79.6 mi
1h 30m
MS 25
43.5 mi
50m
US Highway 45 Alternate
34.6 mi
42m
Martin Luther King Drive
18.1 mi
20m
I 22
14.3 mi
15m
Lakeland Drive
13.1 mi
16m
South Eason Boulevard
4.9 mi
7m
Clinton Boulevard
3.8 mi
6m
Longest stretch:
MS Hwy 25
— 79.6 mi, about 1h 30m
Turn-by-Turn Driving Directions
Step-by-step road directions between Clinton, MS and Itawamba County, MS.
1
Start on Dunton Road
452 ft·22 sec·Dunton Road
2
Turn right onto Hester Street
0.1 mi·28 sec·Hester Street
3
Turn left onto East Leake Street
310 ft·13 sec·East Leake Street
4
Continue on East Leake Street
0.5 mi·1 min·East Leake Street
5
At end of road, turn right onto West Lakeview Drive
0.3 mi·43 sec·West Lakeview Drive
6
Turn left onto Clinton Boulevard
3.8 mi·6 min·Clinton Boulevard
7
Continue on West Capitol Street
0.1 mi·14 sec·West Capitol Street
8
Keep slight left at fork onto Bullard Street
1.3 mi·2 min·Bullard Street
9
Continue on West Woodrow Wilson Avenue
2.9 mi·5 min·West Woodrow Wilson Avenue
10
Turn left onto US 51
0.3 mi·30 sec·North State Street
11
Turn slight right onto Old Canton Road
0.2 mi·16 sec·Old Canton Road
12
Turn right onto Lakeland Drive
13 mi·16 min·Lakeland Drive
13
Continue on MS 25
80 mi·1 hr 30 min·MS Hwy 25
14
Take the exit onto MS 25
25 mi·29 min·MS 25
15
Keep slight right at fork onto MS 25
2.4 mi·2 min·MS 25
Use the left lane.
16
Continue on MS 25
3.8 mi·4 min·MS 25
17
Keep slight right at fork onto MS 25
12 mi·13 min·MS 25
Toward US 82 East, MS 25 North: Columbus, West Point
18
Take the exit
0.3 mi·34 sec
Toward US 45 Alternate North, MS 25 North: West Point, Tupelo
19
Merge onto US 45 ALT; MS 25
35 mi·42 min·US Highway 45 Alternate
Use the straight lane.
20
Continue on US 45 ALT
18 mi·20 min·Martin Luther King Drive
21
Take the exit
0.3 mi·38 sec
Toward Eason Boulevard
22
Turn straight onto South Eason Boulevard
4.9 mi·7 min·South Eason Boulevard
23
Continue on CR 931
0.1 mi·20 sec·Auburn Road
24
Take the ramp
0.3 mi·45 sec
25
Merge onto I 22; US 78
14 mi·15 min·I 22; US 78
26
Take the exit
0.3 mi·41 sec
Toward Fulton, Amory
27
Turn slight left onto South Adams Street
2.2 mi·3 min·South Adams Street
28
Turn right onto MS 178
2.4 mi·4 min·East Main Street
29
Turn left onto Walton Road Southwest
0.2 mi·35 sec·Walton Road Southwest
30
Arrive at destination
Walton Road Southwest
Trip Plan
Given the 4-hour 35-minute estimated drive time, leaving in the morning should give you ample daylight to reach your destination comfortably. With only one suggested stop and a fuel cost estimated at $33, this route is quite efficient. The longest continuous stretch is nearly 80 miles on MS Hwy 25, so plan for a break before or after this segment if needed. Since this is a one-day trip, you have the flexibility to depart later if your schedule requires it, but be mindful of the estimated duration.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 111.9 miles from Clinton, MS, or about 2h 17m into the drive.
The longest continuous stretch on this route runs about 79.6 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 49 miles or 1h 5m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 111.9 miles or 2h 17m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 42m
Traffic, exits, and arrival timing usually matter more near Itawamba County, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Clinton, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Clinton, MS
This is one driving day of about 223.9 miles and 4h 35m.
Your first comfortable stop window is around 49 miles from Clinton, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on MS Hwy 25 for about 79.6 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 16
5 decision points cluster between mile 0.1 and 146.1 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
0.1 mi into trip|~0m in|Hester Street
Turn right onto Hester Street
Navigation decision point
6
127.3 mi into trip|~2h 35m in|MS 25
Keep slight right at fork onto MS 25
Highway fork - watch signs carefully. Lane positioning matters here
Use the left lane.
6
133.5 mi into trip|~2h 42m in|MS 25
Keep slight right at fork onto MS 25 toward US 82 East, MS 25 North: Columbus, West Point
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 82 East, MS 25 North: Columbus, West...
5
145.9 mi into trip|~2h 56m in
Take the exit toward US 45 Alternate North, MS 25 North: West Point, Tupelo
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward US 45 Alternate North, MS 25 North: West...
5
146.1 mi into trip|~2h 57m in|US 45 ALT; MS 25 / US Highway 45 Alternate
Merge onto US 45 ALT; MS 25 / US Highway 45 Alternate
Merge point - match speed before joining. Lane positioning matters here
Use the straight lane.
Fuel & Cost
Regular Gas
$34.85 one way
$69.71 round trip
$3.95/gal25.4 MPG avg78 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$38.42
$76.85
premium
$4.71
$41.53
$83.05
diesel
$6.18
$54.47
$108.94
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$35
Meals
$25–$50
Total
$60–$85
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 78.3 kg one way.
Prices: EIA weekly data, 2026-10-12.
Driving Electric?
About $24 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
67.2
0
$23.51
$10.75
Efficient EV
56
0
$19.59
$8.96
EV Truck/SUV
89.6
1
$31.35
$14.33
Gas CO2
78 kg
EV CO2
26 kg (67% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Oct 16, 2026
Origin
Clinton, MS
Morning
in Clinton on Saturday
Local time
8:02 AM
CDT
Current temp
82°F
Mostly Sunny
NW 5 to 20 mph1% chanceLive forecast
Wind Advisory
Wind Advisory issued October 16 at 7:45AM CDT until October 17 at 7:00PM CDT by NWS Mobile AL
Fire Weather Watch
Fire Weather Watch issued October 16 at 7:42AM CDT until October 17 at 7:00PM CDT by NWS Mobile AL
Destination
Itawamba County, MS
Morning
in Itawamba County on Saturday
Local time
8:02 AM
CDT
Current temp
77°F
Mostly Cloudy then Slight Chance Rain Showers
NW 5 to 20 mph17% chanceLive forecast
Wind Advisory
Wind Advisory issued October 16 at 7:45AM CDT until October 17 at 7:00PM CDT by NWS Mobile AL
Fire Weather Watch
Fire Weather Watch issued October 16 at 7:42AM CDT until October 17 at 7:00PM CDT by NWS Mobile AL
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
5 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 35m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
In July, 1864, federal forces, including men from the United States Colored Troops, marched into Tupelo, Mississippi. Disorganized Confederate soldiers fought fiercely but could not overpower the fede...
4 mi from route
~10 min detour
Free
near mile 200.7
The Natchez Trace National Scenic Trail is five sections of hiking trail running roughly parallel to the 444-mile long Natchez Trace Parkway scenic motor road. The foot trails total more than 60 miles...
7 mi from route
~17 min detour
Free
near mile 200.7
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This route is predominantly highway driving, with 77% of the total mileage on major roads. You'll experience a longest stretch of 79.6 miles on MS Hwy 25, offering a solid period of consistent cruising. The transition to surface roads will occur after this extensive highway segment. Expect a driving experience characterized by the efficiency of main roads for most of the trip.
77% highway — fuel and pacing are the main things to plan.
30 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 79.6 mi on MS Hwy 25.
How Hard Is This Drive?
7/10
This is a straightforward highway drive that stays mostly on MS Hwy 25 and MS 25. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 0.1 miles in near Hester Street.
Driving Effort7/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 16 significant decision points across 223.9 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 0.1 miles (Hester Street): Navigation decision point; at 127.3 miles (MS 25): Highway fork - watch signs carefully. Lane positioning matters here; at 133.5 miles (MS 25): Highway fork - watch signs carefully. Multiple destination signs - pick the right one.
Elevation Profile
Mostly flat terrain
498 ft248 ft
Total Climb
374 ft
Total Descent
341 ft
Highest Point
498 ft
~79.9 mi in
Elevation Range
250 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Clinton, MS and Itawamba County, MS, road signs point toward Point and Tupelo.
Doable as a same-day drive at 4h 35m. Total distance: 223.9 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 35m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (77%). Some complex stretches to watch for.
Frequently Asked Questions
The longest stretch is about 79.6 miles on MS Hwy 25. The full list of main roads is in the Roads section above.
Yes — we found about 2 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Itawamba County, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. There are 2 rest areas along the route for bathroom stops.
The main spots that need attention: at 0.1 miles (Hester Street): Navigation decision point; at 127.3 miles (MS 25): Highway fork - watch signs carefully. Lane positioning matters here; at 133.5 miles (MS 25): Highway fork - watch signs carefully. Multiple destination signs - pick the right one.
Yes — Medgar and Myrlie Evers Home National Monument, Tupelo National Battlefield and Natchez Trace National Scenic Trail. See the National Parks section for detour distances and tips on detours.
Possible but tiring. At 4.6 hours each way, an in-and-out day trip would put you behind the wheel for 9.2 hours — manageable with a long break at Itawamba County, MS, but most travelers stay overnight.
