Spanning 407 miles across the Northeast, this drive from Byron to Islip is a significant commitment that typically takes about 7 hours and 1 minute to complete. Because you will be navigating local roads like Byron Holley Road, Griswold Road, and Lake Street Road rather than major interstates, this journey functions best as a dedicated, full-day excursion. You should budget approximately $66 for fuel to cover the distance. While it is possible to complete the trip in one day, the turn-heavy nature of the route requires your full attention behind the wheel. Use this route if you prefer a cross-state transit that avoids the monotony of typical highway travel.
Trip Pace
Best split across 2 days
Treat the return leg as its own travel day rather than an afterthought.
Break Rhythm
2 planned breaks
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
192.2 miles from Byron, NY
A natural place for your longest stop of the day
, about 4h 7m into the drive
.
Main Roads
Road
Distance
Duration
I 81
98.8 mi
1h 57m
Keystone Shortway
80 mi
1h 37m
New York State Thruway
57.9 mi
1h 6m
Southern State Parkway
24.7 mi
31m
I 380
23.6 mi
25m
East Lake Road
9.9 mi
14m
State Highway 41
9.8 mi
13m
Clark Street Road
9.6 mi
11m
Longest stretch:
I 81
— 98.8 mi, about 1h 57m
Turn-by-Turn Driving Directions
Step-by-step road directions between Byron, NY and Islip, NY.
1
Start on NY 262
141 ft·11 sec·Townline Road
2
Turn left onto NY 237
3.2 mi·5 min·Byron Holley Road
3
Turn left onto Griswold Road
4.9 mi·6 min·Griswold Road
4
At end of road, turn left onto NY 19
0.2 mi·21 sec·Lake Street Road
5
Take the ramp
0.1 mi·14 sec
Toward I 90, I 490 West: Buffalo, New York State Thruway
6
Merge onto I 490
0.1 mi·7 sec·Western Expressway
7
Keep slight left at fork
0.6 mi·1 min
Toward I 90 East: Albany
8
Merge onto I 90
58 mi·1 hr 6 min·New York State Thruway
9
Take the exit
0.5 mi·58 sec
Exit 41Toward NY 414: Waterloo, ClydeUse the slight right lane.
10
Keep slight right at fork
327 ft·7 sec
11
Continue on NY 414
0.3 mi·35 sec·State Route 414
12
Turn left onto NY 318
4.1 mi·7 min·NY 318
Use the left lane.
13
At end of road, turn left onto US 20; NY 5
1.9 mi·2 min·Auburn Road
14
Continue on US 20; NY 5
9.6 mi·11 min·Clark Street Road
Use the straight lane.
15
Turn right onto State Street
226 ft·12 sec·State Street
16
Turn left onto Dill Street
0.1 mi·21 sec·Dill Street
17
Continue on Loop Road
458 ft·16 sec·Loop Road
18
Turn left onto Genesee Street
5.5 mi·9 min·Genesee Street
19
Continue on US 20
2.2 mi·4 min·West Genesee Street Road
20
Turn right onto NY 41
0.5 mi·45 sec·East Lake Street
21
Continue on NY 41
9.4 mi·13 min·East Lake Road
22
Continue on NY 41
4.8 mi·7 min·State Route 41
23
Continue on NY 41
0.5 mi·49 sec·East Lake Road
24
Continue on NY 41
9.8 mi·13 min·State Highway 41
25
Turn right onto NY 281
1.2 mi·2 min·North West Street
26
Take the ramp
0.7 mi·1 min
Use the left lane.
27
Keep slight right at fork
0.3 mi·34 sec
Toward I 81 South: Binghamton
28
Merge onto I 81
45 mi·54 min·I 81
Use the straight / slight right lanes.
29
Keep slight right at fork onto I 81
53 mi·1 hr 3 min·I 81
Toward I 81 South: ScrantonUse the straight lane.
30
Keep slight right at fork onto US 6
0.8 mi·1 min·US 6
Exit 187Toward I 84 East, I 380 South, US 6 East: Carbondale, Mt PoconoUse the slight left / slight right lanes.
31
Continue on I 84; I 380
3.7 mi·4 min·I 84; I 380
Toward I 84 East, I 380 South: Mount Pocono, MilfordUse the straight lane.
32
Keep slight right at fork onto I 380
24 mi·25 min·I 380
Exit 4Toward I 380 South: Mount Pocono
33
Keep slight left at fork
1.0 mi·1 min
Exit 1BToward I 80 East: Stroudsburg
34
Merge onto I 80
80 mi·1 hr 37 min·Keystone Shortway
Use the straight / right lanes.
35
Keep slight right at fork onto I 80
5.5 mi·5 min·Christopher Columbus Highway
Toward I 95: George Washington Bridge Lower LevelUse the slight right lane.
36
Keep slight left at fork
0.3 mi·23 sec
Toward I 95 North: George Washington Bridge, New York CityUse the straight / slight right lanes.
37
Keep slight right at fork
0.4 mi·38 sec
Exit 70A-BToward Leonia, TeaneckUse the slight right lane.
38
Turn right
0.2 mi·35 sec
Exit 70AToward LeoniaUse the straight / slight right lanes.
39
Turn straight onto CR 56
454 ft·9 sec·Degraw Avenue
40
Continue on CR 56
1.1 mi·2 min·Fort Lee Road
Use the straight / right lanes.
41
Continue on CR 56
469 ft·13 sec·Main Street
42
Take the ramp
472 ft·12 sec
Toward George Washington Bridge
43
Merge onto US 1; US 9; US 46
0.3 mi·28 sec·Bergen Boulevard
Use the straight / slight right lanes.
44
Take the exit
312 ft·4 sec
Toward George Washington Bridge Upper Level
45
Merge onto I 95 EXPR
0.3 mi·20 sec·I 95 EXPR
Use the straight / slight right lanes.
46
Keep slight left at fork onto I 95 EXPR
0.8 mi·1 min·I 95 EXPR
47
Continue on I 95; US 1; US 9
0.6 mi·1 min·George Washington Bridge (upper level)
Use the straight / slight right lanes.
48
Continue on I 95; US 1
0.7 mi·1 min·Trans-Manhattan Expressway
49
Continue on I 95; US 1
4.7 mi·6 min·Cross Bronx Expressway
Use the straight / slight right lanes.
50
Keep slight right at fork onto I 295
2.0 mi·2 min·Cross Bronx Expressway
Exit 6BToward I 295 South: Throgs Neck BridgeUse the straight / slight left lanes.
51
Merge onto I 295
0.6 mi·58 sec·Throgs Neck Expressway
52
Continue on I 295
2.0 mi·3 min·Throgs Neck Bridge
Use the straight / slight right lanes.
53
Continue on I 295
5.0 mi·5 min·Clearview Expressway
Use the straight / slight right lanes.
54
Continue on NY 24
0.7 mi·1 min·Hollis Court Boulevard
Use the straight lane.
55
At end of road, turn left onto NY 24
0.2 mi·35 sec·Jamaica Avenue
Use the left lane.
56
Turn right onto Hempstead Avenue
0.9 mi·2 min·Hempstead Avenue
57
Turn right onto 225th Street
228 ft·9 sec·225th Street
Use the right lane.
58
Take the ramp
0.2 mi·28 sec
Toward Cross Island Parkway South, Verrazano Bridge
59
Merge onto CI
1.3 mi·1 min·Cross Island Parkway
Use the straight / slight right lanes.
60
Take the exit
0.5 mi·1 min
Exit 25AToward Southern State Parkway East, Eastern Long IslandUse the slight left / straight lanes.
61
Merge onto SO
25 mi·31 min·Southern State Parkway
Use the straight / slight right lanes.
62
Keep slight left at fork onto SO
0.2 mi·16 sec·Southern State Parkway
Use the straight / slight right lanes.
63
Take the exit
0.2 mi·31 sec
Exit 41SToward Bay Shore Road South, Bay ShoreUse the slight right lane.
64
Turn straight onto CR 57
0.5 mi·1 min·Bay Shore Road
65
Continue on CR 57
0.3 mi·43 sec·Howells Road
66
Turn straight onto CR 57
341 ft·6 sec·Sunrise Highway
67
Keep slight right at fork onto CR 57
0.6 mi·1 min·Howells Road
Toward Howells Road SouthUse the right lane.
68
Continue on CR 57
0.2 mi·24 sec·Roosevelt Street
69
Continue on CR 57
0.7 mi·1 min·3rd Avenue
70
At end of road, turn left onto NY 27A
1.1 mi·1 min·East Main Street
71
Continue on Montauk Highway
0.2 mi·17 sec·Montauk Highway
72
Continue on NY 27A
0.8 mi·1 min·Main Street
73
Arrive at destination
NY 27A
Trip Plan
Plan for a long day on the road by departing early to maximize daylight, as the 7-hour duration can feel more strenuous on local roads than on a highway. Incorporating at least 2 stops is essential to break up the drive and manage the fatigue that comes with constant turning. Since you are relying on local roads, keep an eye on your fuel gauge throughout the journey to ensure you do not run low between smaller towns. Given the $66 fuel estimate, try to refuel in larger, more competitive markets to keep your costs stable. Flexibility is your greatest asset here, so be prepared to adjust your pace if you encounter unexpected traffic on the local stretches.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
This drive is better paced as a 2-day trip.
Plan roughly 2 meaningful breaks for fuel, food, and rest.
The halfway point lands around 192.2 miles from Byron, NY, or about 4h 7m into the drive.
The longest continuous stretch on this route runs about 98.8 miles.
Consider an overnight stop or starting very early.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 85 miles or 1h 46m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 192.2 miles or 4h 7m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Overnight split
Day 1 wrap after about 192.2 miles or 4h 7m
Stop before fatigue turns the last few hours into a grind. You want day two to start fresh, not just resumed.
Final approach
Final hour starts around 6h 45m
Traffic, exits, and arrival timing usually matter more near Islip, NY than in the middle of the route.
Before You Leave
+
Open the route before leaving Byron, NY so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
+
Pick one backup stop option before the midpoint in case traffic changes your pacing.
+
Treat this as a 2-day road trip and book the overnight stop before the busiest arrival window.
Day 1
Settle into the route from Byron, NY
Aim for roughly 192 miles and 4.1 hours of wheel time on this day.
Day 2
Finish the approach into Islip, NY
Aim for roughly 192 miles and 4.1 hours of wheel time on this day.
Your first comfortable stop window is around 85 miles from Byron, NY.
This route usually feels better as a 2-day drive than as one long push.
Plan about 2 real breaks rather than only quick fuel stops.
The longest stretch is on I 81 for about 98.8 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 47
5 decision points cluster between mile 67 and 379.8 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
8
67 mi into trip|~1h 21m in
Take the exit toward NY 414: Waterloo, Clyde
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 41
Toward NY 414: Waterloo, Clyde
9
217.3 mi into trip|~4h 37m in|US 6
Keep slight right at fork onto US 6 toward I 84 East, I 380 South, US 6 East: Carbondale, Mt Pocono
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Exit 187
Toward I 84 East, I 380 South, US 6 East: Carbo...
8
331.9 mi into trip|~6h 53m in
Keep slight left at fork toward I 95 North: George Washington Bridge, New York City
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward I 95 North: George Washington Bridge, Ne...
9
332.2 mi into trip|~6h 54m in
Keep slight right at fork toward Leonia, Teaneck
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 70A-B
Toward Leonia, Teaneck
9
379.8 mi into trip|~8h in
Take the exit toward Bay Shore Road South, Bay Shore
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 41S
Toward Bay Shore Road South, Bay Shore
Fuel & Cost
Regular Gas
$63.27 one way
$126.55 round trip
$4.18/gal25.4 MPG avg135 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.52
$68.42
$136.84
premium
$4.92
$74.50
$149.01
diesel
$5.61
$84.87
$169.74
Estimated Tolls: $25.44
George Washington Bridge
$16.00
Throgs Neck Bridge
$6.55
New York State Thruway
(57.9 mi)$2.89
Toll estimates based on average 2024-2025 rates. EZ-Pass/SunPass discounts may lower the actual cost.
Estimated Trip Cost (one way, 1 person)
Fuel
$63
Tolls
$25
Hotel (1n)
$80–$140
Meals
$50–$100
Total
$219–$329
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 134.5 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $40 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
115.3
1
$40.36
$18.45
Efficient EV
96.1
1
$33.64
$15.38
EV Truck/SUV
153.8
1
$53.82
$24.60
Gas CO2
134 kg
EV CO2
45 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Byron, NY
Late night
in Byron on Sunday
Local time
1:59 AM
EDT
Current temp
58°F
Unavailable
Live forecast
Destination
Islip, NY
Late night
in Islip on Sunday
Local time
1:59 AM
EDT
Current temp
44°F
Unavailable
Live forecast
49°F
Ramapo, NY
192 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
For long drives, weather on day two can matter just as much as conditions at departure, so check the whole travel window rather than only the first day.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
14 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
8h 9m on the road
This is long enough that the arrival forecast matters almost as much as departure conditions. Recheck both ends before you roll.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
Expect a technical and engaging experience, as this route is defined by its turn-heavy local road profile rather than high-speed highway cruising. With a highway share of 0%, you will spend your entire time navigating surface streets, which keeps the driving pace deliberate and varied. The route demands constant engagement, meaning you will rarely find yourself on long, uninterrupted stretches. Transitioning through the local landscape requires patience and focus, as the road conditions will shift frequently as you move toward your destination. It is a practical alternative for drivers who find standard interstate driving tedious and prefer a more hands-on, localized driving experience.
Only 48% highway — the rest is turn-by-turn surface driving.
73 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 98.8 mi on I 81.
How Hard Is This Drive?
10/10
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 67 miles in.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 47 significant decision points across 384.4 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 67 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 217.3 miles (US 6): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 331.9 miles: Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Byron, NY and Islip, NY, road signs point toward Clyde, Mt Pocono, Milford, New York City, Leonia and Teaneck - among others.
Islip (pronounced "ICE-lip") is a town on Long Island in the state of New York. Located within Suffolk County, the Town of Islip includes the villages of Brightwaters, Islandia, Ocean Beach and Saltaire. It also includes numerous hamlets including Bay Shore and Sayville which are ferry terminals for Fire Island. Other prominent communities are Bayport, Brentwood, Central Islip, Hauppauge, Islip village (the town seat), and Ronkonkoma.
Top landmarks
•Bayport Aerodrome — airport in Suffolk County, New York, United States
•Connetquot River State Park Preserve — state park in New York
•Modesty — oyster-dredging sloop built in Long Island
The longest stretch is about 98.8 miles on I 81. The full list of main roads is in the Roads section above.
Yes — a 2-day pace is more comfortable than one long haul. A sensible stopping point is after roughly 192 miles on day one.
Expect about $25.44 in tolls one way, starting with George Washington Bridge. Most Northeast and Midwest toll agencies accept E-ZPass; in the West and Texas, transponders like TxTag or FasTrak apply. If you do not have a transponder, cashless tolling plates will mail a bill to the vehicle's registered address — usually with a surcharge, so a rental-car toll pass is often cheaper than paying by mail.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Islip, NY before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 2 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 67 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 217.3 miles (US 6): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 331.9 miles: Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Not recommended in a single day. At 8.2 hours each way, a round trip means 16.3 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Islip, NY before the return drive.
