This 327.2-mile journey from Bokeelia, Florida, to Jacksonville, Florida, is a solid day trip, estimated to take around 6 hours and 33 minutes of driving time. With 89% of the route on highways, it's a primarily interstate-focused drive, making it an efficient way to cover ground between these two Florida locations. You'll want to budget approximately $52 for fuel, and the single recommended stop suggests a relatively straightforward trip. This route is well-suited for a single day, allowing you to reach your destination without needing an overnight stay.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
163.6 miles from Bokeelia, FL
A natural place for your longest stop of the day
, about 3h 18m into the drive
.
Main Roads
Road
Distance
Duration
I 75
195.6 mi
3h 30m
US 301
75.9 mi
1h 34m
I 10
16.8 mi
19m
Burnt Store Road North
16 mi
22m
Stringfellow Road
7.1 mi
17m
Pine Island Road Northwest
3.9 mi
7m
Burnt Store Road South
2 mi
3m
Southwest Pine Island Road
1.5 mi
2m
Longest stretch:
I 75
— 195.6 mi, about 3h 30m
Turn-by-Turn Driving Directions
Step-by-step road directions between Bokeelia, FL and Jacksonville, FL.
1
Start on CR 767
0.1 mi·15 sec·Main Street
2
Continue on CR 767
7.1 mi·17 min·Stringfellow Road
3
Turn left onto CR 78
3.9 mi·7 min·Pine Island Road Northwest
Use the left lane.
4
Continue on CR 78
1.5 mi·2 min·Southwest Pine Island Road
5
Turn left onto CR 765
2.0 mi·3 min·Burnt Store Road South
Use the left lane.
6
Keep slight right at fork onto CR 765
16 mi·22 min·Burnt Store Road North
Use the left lane.
7
Continue on CR 768
1.4 mi·2 min·Jones Loop Road
8
Take the exit
0.4 mi·58 sec
Toward I 75 North: Tampa
9
Merge onto I 75
196 mi·3 hr 30 min·I 75
Use the straight / slight right lanes.
10
Take the exit
0.2 mi·32 sec
Exit 358Toward FL 326Use the straight / slight right lanes.
11
Turn slight right
144 ft·4 sec
12
Turn slight right onto FL 326
1.1 mi·1 min·FL 326
Use the straight / right lanes.
13
Continue on FL 326
1.5 mi·2 min·Northwest 70th Street
14
Turn left onto US 301; US 441
5.5 mi·6 min·US 301; US 441
Use the left lane.
15
Turn straight onto US 301
52 mi·1 hr 5 min·US 301
Toward North US 301: StarkeUse the straight lane.
16
Continue on US 301
18 mi·22 min·US 301
17
Take the exit
0.9 mi·1 min
Toward I 10 East: Jacksonville
18
Merge onto I 10
17 mi·19 min·I 10
Use the straight / slight right lanes.
19
Take the exit
0.4 mi·33 sec
Toward I 95 South: Jacksonville Beaches, Daytona Beach
20
Keep slight left at fork
0.7 mi·56 sec
Toward I 95 North: International Airport, SavannahUse the slight left / slight right lanes.
21
Merge onto I 95
0.7 mi·1 min·I 95
22
Take the exit onto US 17; FL 228
0.2 mi·26 sec·US 17; FL 228
Exit 353BToward Union Street, Beaver Street
23
Turn straight onto US 17; US 23; FL 228
0.7 mi·1 min·Union Street
Use the straight / left lanes.
24
Arrive at destination
US 17
Trip Plan
For this 6-hour and 33-minute drive, consider an early morning departure from Bokeelia to maximize daylight and minimize potential traffic. With a fuel cost estimate of $52, it's wise to fill up before you leave or at a convenient point along I-75, which hosts the longest stretch at 195.6 miles. While the route has only one recommended stop, plan for brief breaks as needed to stay refreshed. Given it's a manageable day trip, you have flexibility in your timing, but keeping an eye on highway conditions, especially on I-75 and I-10 as you approach Jacksonville, is always a good idea.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 163.6 miles from Bokeelia, FL, or about 3h 18m into the drive.
The longest continuous stretch on this route runs about 195.6 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 72 miles or 1h 39m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 163.6 miles or 3h 18m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 5h 18m
Traffic, exits, and arrival timing usually matter more near Jacksonville, FL than in the middle of the route.
Before You Leave
+
Open the route before leaving Bokeelia, FL so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Bokeelia, FL
This is one driving day of about 327.2 miles and 6h 33m.
Your first comfortable stop window is around 72 miles from Bokeelia, FL.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 75 for about 195.6 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 16
5 decision points cluster between mile 7.2 and 326.3 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
7.2 mi into trip|~17m in|CR 78 / Pine Island Road Northwest
Turn left onto CR 78 / Pine Island Road Northwest
Lane positioning matters here
Use the left lane.
6
14.6 mi into trip|~30m in|CR 765 / Burnt Store Road North
Keep slight right at fork onto CR 765 / Burnt Store Road North
Highway fork - watch signs carefully. Lane positioning matters here
Use the left lane.
7
228.1 mi into trip|~4h 27m in
Take the exit toward FL 326
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the straight / slight right lanes.
Exit 358
Toward FL 326
8
324.9 mi into trip|~6h 29m in
Keep slight left at fork toward I 95 North: International Airport, Savannah
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward I 95 North: International Airport, Savan...
6
326.3 mi into trip|~6h 31m in|US 17; FL 228
Take the exit onto US 17; FL 228 toward Union Street, Beaver Street
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 353B
Toward Union Street, Beaver Street
Fuel & Cost
Regular Gas
$52.08 one way
$104.16 round trip
$4.04/gal25.4 MPG avg115 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.40
$56.65
$113.31
premium
$4.72
$60.84
$121.68
diesel
$5.61
$72.24
$144.48
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$52
Meals
$25–$50
Total
$77–$102
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 114.5 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $34 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
98.2
1
$34.36
$15.71
Efficient EV
81.8
0
$28.63
$13.09
EV Truck/SUV
130.9
1
$45.81
$20.94
Gas CO2
114 kg
EV CO2
38 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 20, 2026
Origin
Bokeelia, FL
Morning
in Bokeelia on Tuesday
Local time
8:34 AM
EDT
Current temp
80°F
Unavailable
Live forecast
Destination
Jacksonville, FL
Morning
in Jacksonville on Tuesday
Local time
8:34 AM
EDT
Current temp
89°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
9 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 33m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
De Soto National Memorial
National Memorial
In May 1539, Conquistador Hernando de Soto’s army of soldiers, hired mercenaries, craftsmen, and clergy made landfall in Tampa Bay. They were met with fierce resistance of indigenous people protecting...
11 mi from route
~26 min detour
Free
near mile 101.6
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
Expect a highway-focused drive for the majority of this trip, with 89% of the 327.2 miles covered on interstates and major highways like I-75, US-301, and I-10. The longest uninterrupted stretch you'll encounter is a significant 195.6 miles on I-75, so be prepared for extended periods of consistent highway speeds. This profile suggests a drive that prioritizes direct travel over winding scenic byways, offering a steady pace for most of the journey.
89% highway — fuel and pacing are the main things to plan.
24 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 195.6 mi on I 75.
How Hard Is This Drive?
8/10
This is a straightforward highway drive that stays mostly on I 75 and US 301. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 7.2 miles in near CR 78 / Pine Island Road Northwest.
Driving Effort8/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 16 significant decision points across 327.2 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 7.2 miles (CR 78 / Pine Island Road Northwest): Lane positioning matters here; at 14.6 miles (CR 765 / Burnt Store Road North): Highway fork - watch signs carefully. Lane positioning matters here; at 228.1 miles: Exit ramp - move to the correct lane early. Lane positioning matters here.
Jacksonville occupies one of the most coveted spots on the Atlantic coast. Set amongst abundant beaches and possessing an ideal subtropical climate, its crown jewel is the unique habitat and natural beauty of the St. Johns River. For this reason and more, "The River City" is a popular destination for vacationers looking for a laid-back Sunshine State escape.
Top landmarks
•Fort Caroline — fort in Florida managed by the National Park Service
•Museum of Contemporary Art Jacksonville — museum in Jacksonville, Florida
•Timucuan Ecological and Historic Preserve — wetlands in Florida (U.S.) managed by the National Park Service
Doable as a same-day drive at 6h 33m. Total distance: 327.2 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 33m drive, plan rest stops for pacing.
Frequently Asked Questions
The longest stretch is about 195.6 miles on I 75. The full list of main roads is in the Roads section above.
Yes — we found about 33 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Jacksonville, FL before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. There are 33 rest areas along the route for bathroom stops.
The main spots that need attention: at 7.2 miles (CR 78 / Pine Island Road Northwest): Lane positioning matters here; at 14.6 miles (CR 765 / Burnt Store Road North): Highway fork - watch signs carefully. Lane positioning matters here; at 228.1 miles: Exit ramp - move to the correct lane early. Lane positioning matters here.
Yes — De Soto National Memorial. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 6.6 hours each way, a round trip means 13.1 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Jacksonville, FL before the return drive.
